Nicotinamide

Vitamin

CAS no. 98-92-0

Nicotinamide, othewrise known as Niacinamide, a derivative of vitamin B3, is a nutrient present in various foods and utilized as both a dietary supplement and medicinal aid.

When taken orally, it serves to prevent and address pellagra, a condition resulting from niacin deficiency.

Furthermore, in cream form, it showcases effectiveness in treating acne, while clinical studies suggest its role in enhancing aging skin by minimizing hyperpigmentation and redness.

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Nicotinamide, a derivative of vitamin B3, stands as a pivotal compound renowned for its multifaceted roles in various biological processes.

Historical Evolution

Nicotinamide, also known as niacinamide, traces its origins to the discovery of vitamin B3 in the early 20th century. Scientists identified its vital role in the human body's metabolism, particularly in energy production and cellular function. The compound gained recognition for its therapeutic potential, leading to its incorporation into various medical treatments and dietary supplements.

Properties

Chemical Composition and Structure:

Nicotinamide, a water-soluble amide form of niacin (vitamin B3), features a pyridine ring structure. This structure enables its involvement in essential biochemical pathways, including the synthesis of coenzymes vital for cellular metabolism.

Metabolic Role:

As a precursor to coenzymes like nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+), nicotinamide plays a fundamental role in cellular energy production, redox reactions, and DNA repair mechanisms.

Skin Benefits:

Nicotinamide exhibits anti-inflammatory properties, making it valuable in skincare formulations. Its role in supporting the skin barrier function, reducing redness, and managing acne has garnered attention in dermatology.

Uses

Medical Applications:

Treatment of Pellagra: Nicotinamide serves as a fundamental treatment for pellagra, a condition caused by vitamin B3 deficiency, showcasing its significance in preventing and managing nutritional deficiencies.
Dermatological Treatments: Its anti-inflammatory and skin barrier-enhancing properties make nicotinamide an essential ingredient in skincare products, aiding in conditions like acne, eczema, and hyperpigmentation.

Health Supplements:

Nicotinamide supplements are widely used to support overall health, particularly in individuals with dietary deficiencies or specific health conditions requiring additional vitamin B3 intake.

Benefits

Energy Production:

As a precursor to NAD+ and NADP+, nicotinamide contributes to efficient energy metabolism within cells, promoting vitality and overall energy levels.

Skin Health:

Nicotinamide's anti-inflammatory and skin barrier-strengthening properties benefit skin health, aiding in conditions such as acne, rosacea, and aging-related skin concerns.

Neuroprotection:

Research indicates nicotinamide's potential neuroprotective effects, showing promise in managing neurological conditions and supporting cognitive function.

Nicotinamide, with its rich history, versatile properties, and diverse applications, remains an indispensable compound in medicine, skincare, and overall wellness. Its pivotal role in cellular metabolism, skin health, and potential therapeutic benefits showcases its significance in promoting human health and quality of life. Ongoing research and advancements continue to uncover new avenues for its utilization, emphasizing nicotinamide's enduring importance in modern health sciences.

References

Bitterman KJ, Chung JH. Metabolic Effects of NAD+ on Healthspan and Lifespan. Annu Rev Biochem. 2020 Jun 20;89:131-153. doi: 10.1146/annurev-biochem-013118-111957. Epub 2019 Dec 4. PMID: 31805172.
Knip M, Douek IF, Moore WP, et al. Safety of high-dose nicotinamide: a review. Diabetologia. 2000 Aug;43(8):1337-45. doi: 10.1007/s001250051536. PMID: 10990095.
Działo M, Mierziak J, Korzun U, Preisner M, Szopa J, Kulma A. The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders. Int J Mol Sci. 2016 Aug 12;17(2):160. doi: 10.3390/ijms17020160. PMID: 27529212; PMCID: PMC4783895.